Can't calculate the pair potential

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Excuse me,I'm an university student and I have interest about your paper:MODEL-BASED REINFORCEMENT LEARNING FOR BIOLOGICAL SEQUENCE DESIGN.However,I have a little question about protein contact Ising Model.The experiment have used a pair potential based on co-occurence probabilities derived from reference.But I don't how to calculate the pair potential from reference.so could you tell me the values of this potential or how to calculate it.I would appreciate it very much if you could reply to me.Thank you very much.