diff --git a/build/build.py b/build/build.py
index 72f15db17f30..df140d9f89d9 100755
--- a/build/build.py
+++ b/build/build.py
@@ -468,6 +468,9 @@ async def main():
       # Enable clang settings that are needed for the build to work with newer
       # versions of Clang.
       wheel_build_command_base.append("--config=clang")
+    if clang_major_version < 19:
+      wheel_build_command_base.append("--define=xnn_enable_avxvnniint8=false")
+
   else:
     gcc_path = args.gcc_path or utils.get_gcc_path_or_exit()
     logging.debug(
@@ -477,6 +480,10 @@ async def main():
     wheel_build_command_base.append(f"--repo_env=CC=\"{gcc_path}\"")
     wheel_build_command_base.append(f"--repo_env=BAZEL_COMPILER=\"{gcc_path}\"")
 
+    gcc_major_version = utils.get_gcc_major_version(gcc_path)
+    if gcc_major_version < 13:
+      wheel_build_command_base.append("--define=xnn_enable_avxvnniint8=false")
+
   if not args.disable_mkl_dnn:
     logging.debug("Enabling MKL DNN")
     if target_cpu == "aarch64":
diff --git a/build/tools/utils.py b/build/tools/utils.py
index 16450ab9eae5..03a762ac3940 100644
--- a/build/tools/utils.py
+++ b/build/tools/utils.py
@@ -201,6 +201,18 @@ def get_clang_major_version(clang_path):
 
   return major_version
 
+def get_gcc_major_version(gcc_path: str):
+  gcc_version_proc = subprocess.run(
+    [gcc_path, "-dumpversion"],
+    check=True,
+    capture_output=True,
+    text=True,
+  )
+  major_version = int(gcc_version_proc.stdout)
+
+  return major_version
+
+
 def get_jax_configure_bazel_options(bazel_command: list[str]):
   """Returns the bazel options to be written to .jax_configure.bazelrc."""
   # Get the index of the "run" parameter. Build options will come after "run" so