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# Instructions | ||
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Each of us inherits from our biological parents a set of chemical instructions known as DNA that influence how our bodies are constructed. | ||
All known life depends on DNA! | ||
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> Note: You do not need to understand anything about nucleotides or DNA to complete this exercise. | ||
DNA is a long chain of other chemicals and the most important are the four nucleotides, adenine, cytosine, guanine and thymine. | ||
A single DNA chain can contain billions of these four nucleotides and the order in which they occur is important! | ||
We call the order of these nucleotides in a bit of DNA a "DNA sequence". | ||
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We represent a DNA sequence as an ordered collection of these four nucleotides and a common way to do that is with a string of characters such as "ATTACG" for a DNA sequence of 6 nucleotides. | ||
'A' for adenine, 'C' for cytosine, 'G' for guanine, and 'T' for thymine. | ||
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Given a string representing a DNA sequence, count how many of each nucleotide is present. | ||
If the string contains characters that aren't A, C, G, or T then it is invalid and you should signal an error. | ||
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For example: | ||
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```text | ||
"GATTACA" -> 'A': 3, 'C': 1, 'G': 1, 'T': 2 | ||
"INVALID" -> error | ||
``` |
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{ | ||
"authors": [ | ||
"keiravillekode" | ||
], | ||
"files": { | ||
"solution": [ | ||
"nucleotide_count.s" | ||
], | ||
"test": [ | ||
"nucleotide_count_test.c" | ||
], | ||
"example": [ | ||
".meta/example.s" | ||
] | ||
}, | ||
"blurb": "Given a DNA string, compute how many times each nucleotide occurs in the string.", | ||
"source": "The Calculating DNA Nucleotides_problem at Rosalind", | ||
"source_url": "https://rosalind.info/problems/dna/" | ||
} |
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.text | ||
.globl nucleotide_counts | ||
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/* extern void nucleotide_counts(int16_t *counts, const char *strand); */ | ||
nucleotide_counts: | ||
mov w4, wzr | ||
mov w5, wzr | ||
mov w6, wzr | ||
mov w7, wzr | ||
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.read: | ||
ldrb w2, [x1], #1 /* load byte, post-increment */ | ||
cbz w2, .report | ||
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cmp w2, 'A' | ||
beq .adenine | ||
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cmp w2, 'C' | ||
beq .cytosine | ||
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cmp w2, 'G' | ||
beq .guanine | ||
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cmp w2, 'T' | ||
beq .thymine | ||
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mov w2, -1 | ||
strh w2, [x0], #2 | ||
strh w2, [x0], #2 | ||
strh w2, [x0], #2 | ||
strh w2, [x0] | ||
ret | ||
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.report: | ||
strh w4, [x0], #2 | ||
strh w5, [x0], #2 | ||
strh w6, [x0], #2 | ||
strh w7, [x0] | ||
ret | ||
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.adenine: | ||
add w4, w4, #1 | ||
b .read | ||
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.cytosine: | ||
add w5, w5, #1 | ||
b .read | ||
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.guanine: | ||
add w6, w6, #1 | ||
b .read | ||
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.thymine: | ||
add w7, w7, #1 | ||
b .read |
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# This is an auto-generated file. | ||
# | ||
# Regenerating this file via `configlet sync` will: | ||
# - Recreate every `description` key/value pair | ||
# - Recreate every `reimplements` key/value pair, where they exist in problem-specifications | ||
# - Remove any `include = true` key/value pair (an omitted `include` key implies inclusion) | ||
# - Preserve any other key/value pair | ||
# | ||
# As user-added comments (using the # character) will be removed when this file | ||
# is regenerated, comments can be added via a `comment` key. | ||
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[3e5c30a8-87e2-4845-a815-a49671ade970] | ||
description = "empty strand" | ||
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[a0ea42a6-06d9-4ac6-828c-7ccaccf98fec] | ||
description = "can count one nucleotide in single-character input" | ||
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[eca0d565-ed8c-43e7-9033-6cefbf5115b5] | ||
description = "strand with repeated nucleotide" | ||
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[40a45eac-c83f-4740-901a-20b22d15a39f] | ||
description = "strand with multiple nucleotides" | ||
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[b4c47851-ee9e-4b0a-be70-a86e343bd851] | ||
description = "strand with invalid nucleotides" |
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AS = aarch64-linux-gnu-as | ||
CC = aarch64-linux-gnu-gcc | ||
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CFLAGS = -g -Wall -Wextra -pedantic -Werror | ||
LDFLAGS = | ||
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ALL_LDFLAGS = -pie -Wl,--fatal-warnings | ||
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ALL_CFLAGS = -std=c99 -fPIE $(CFLAGS) | ||
ALL_LDFLAGS += $(LDFLAGS) | ||
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C_OBJS = $(patsubst %.c,%.o,$(wildcard *.c)) | ||
AS_OBJS = $(patsubst %.s,%.o,$(wildcard *.s)) | ||
ALL_OBJS = $(filter-out example.o,$(C_OBJS) $(AS_OBJS) vendor/unity.o) | ||
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CC_CMD = $(CC) $(ALL_CFLAGS) -c -o $@ $< | ||
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all: tests | ||
qemu-aarch64 -L /usr/aarch64-linux-gnu ./$< | ||
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tests: $(ALL_OBJS) | ||
@$(CC) $(ALL_CFLAGS) $(ALL_LDFLAGS) -o $@ $(ALL_OBJS) | ||
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%.o: %.s | ||
@$(AS) -o $@ $< | ||
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%.o: %.c | ||
@$(CC_CMD) | ||
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vendor/unity.o: vendor/unity.c vendor/unity.h vendor/unity_internals.h | ||
@$(CC_CMD) | ||
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clean: | ||
@rm -f *.o vendor/*.o tests | ||
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.PHONY: all clean |
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.text | ||
.globl nucleotide_counts | ||
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nucleotide_counts: | ||
ret |
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exercises/practice/nucleotide-count/nucleotide_count_test.c
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#include "vendor/unity.h" | ||
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#include <stdint.h> | ||
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#define INVALID -1 | ||
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enum nucleotide { | ||
ADENINE, | ||
CYTOSINE, | ||
GUANINE, | ||
THYMINE | ||
}; | ||
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extern void nucleotide_counts(int16_t *counts, const char *strand); | ||
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void setUp(void) { | ||
} | ||
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void tearDown(void) { | ||
} | ||
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void test_empty_strand(void) { | ||
int16_t counts[4]; | ||
nucleotide_counts(counts, ""); | ||
TEST_ASSERT_EQUAL_INT(0, counts[ADENINE]); | ||
TEST_ASSERT_EQUAL_INT(0, counts[CYTOSINE]); | ||
TEST_ASSERT_EQUAL_INT(0, counts[GUANINE]); | ||
TEST_ASSERT_EQUAL_INT(0, counts[THYMINE]); | ||
} | ||
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void test_can_count_one_nucleotide_in_singlecharacter_input(void) { | ||
TEST_IGNORE(); | ||
int16_t counts[4]; | ||
nucleotide_counts(counts, "G"); | ||
TEST_ASSERT_EQUAL_INT(0, counts[ADENINE]); | ||
TEST_ASSERT_EQUAL_INT(0, counts[CYTOSINE]); | ||
TEST_ASSERT_EQUAL_INT(1, counts[GUANINE]); | ||
TEST_ASSERT_EQUAL_INT(0, counts[THYMINE]); | ||
} | ||
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void test_strand_with_repeated_nucleotide(void) { | ||
TEST_IGNORE(); | ||
int16_t counts[4]; | ||
nucleotide_counts(counts, "GGGGGGG"); | ||
TEST_ASSERT_EQUAL_INT(0, counts[ADENINE]); | ||
TEST_ASSERT_EQUAL_INT(0, counts[CYTOSINE]); | ||
TEST_ASSERT_EQUAL_INT(7, counts[GUANINE]); | ||
TEST_ASSERT_EQUAL_INT(0, counts[THYMINE]); | ||
} | ||
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void test_strand_with_multiple_nucleotides(void) { | ||
TEST_IGNORE(); | ||
int16_t counts[4]; | ||
nucleotide_counts(counts, "AGCTTTTCATTCTGACTGCAACGGGCAATATGTCTCTGTGTGGATTAAAAAAAGAGTGTCTGATAGCAGC"); | ||
TEST_ASSERT_EQUAL_INT(20, counts[ADENINE]); | ||
TEST_ASSERT_EQUAL_INT(12, counts[CYTOSINE]); | ||
TEST_ASSERT_EQUAL_INT(17, counts[GUANINE]); | ||
TEST_ASSERT_EQUAL_INT(21, counts[THYMINE]); | ||
} | ||
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void test_strand_with_invalid_nucleotides(void) { | ||
TEST_IGNORE(); | ||
int16_t counts[4]; | ||
nucleotide_counts(counts, "AGXXACT"); | ||
TEST_ASSERT_EQUAL_INT(INVALID, counts[ADENINE]); | ||
TEST_ASSERT_EQUAL_INT(INVALID, counts[CYTOSINE]); | ||
TEST_ASSERT_EQUAL_INT(INVALID, counts[GUANINE]); | ||
TEST_ASSERT_EQUAL_INT(INVALID, counts[THYMINE]); | ||
} | ||
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int main(void) { | ||
UNITY_BEGIN(); | ||
RUN_TEST(test_empty_strand); | ||
RUN_TEST(test_can_count_one_nucleotide_in_singlecharacter_input); | ||
RUN_TEST(test_strand_with_repeated_nucleotide); | ||
RUN_TEST(test_strand_with_multiple_nucleotides); | ||
RUN_TEST(test_strand_with_invalid_nucleotides); | ||
return UNITY_END(); | ||
} |
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